Abstract: AIM To investigate the feasibility and safety of 3830 active fixation leads in clinical cardiac pacing. METHODS Selected for this study were 225 patients with permanent artificial double-chamber pacemaker implantation in our hospital between 2008 and 2012, including 134 patients with 3830 active fixation leads and 91 patients with 5076 active fixation leads. The pacing parameters and the related complications of the two groups were recorded during and after the procedure and compared accordingly. RESULTS The atrial threshold and impedance in the 3830 lead group were significantly higher than in the 5076 lead group (P<0.05, P<0.01) during and after the procedure. No significant difference was found in atrial perception and ventricular perception between groups. The ventricular threshold was significantly different between groups during and 1 week after the procedure (P<0.05, P<0.01). There was no significant difference in the pacing parameters between different parts of the atrium in the 3830 lead group and there was no significant difference in the complications between groups. CONCLUSION The application of 3830 active fixation leads is feasible and safe in clinical cardiac pacing.