Abstract: AIM To evaluate the efficacy and safety of radiofrequency catheter ablation of atrioventricular nodal reentrant tachycardia (AVNRT) guided by three-dimensional mapping of Ensite Navx. METHODS Radiofrequency ablation of 213 cases of AVNRT patients were divided into three dimensional mapping group (101 cases) and routine treatment group (112 cases), three-dimensional mapping group in Ensite Navx three-dimensional mapping system under the guidance of necessary joint short X-ray ablation; conventional treatment group in the traditional X line fluoroscopy radiofrequency ablation therapy. Observation index: mapping catheter placed in the process of X-ray exposure time and radiation dose; the operation of ablation catheter ablation process modeling X-ray exposure time and radiation dose; operative time; the immediate success rate and success rate of the overall incidence of complications; 5 (hemopneumothorax, cardiac tamponade, III degree atrioventricular block). RESULTS The placement of a mapping catheter in the process of the two groups of X-ray exposure time, exposure dose were: 3D mapping group (2.3±1.3) min, (1.7±1.1) mGy, the conventional treatment group (2.4±1.1) min, (1.6±1.0) mGy, there was no significant differences in the operation of the two; the ablation catheter ablation process, exposure time, exposure dose group X-ray 3D mapping: (2.6±1.8) min, (3.5 ±1.8) mGy, significantly lower than the conventional treatment group (8.9±2) min, (11.8±2.6) mGy, P<0.01. (3) operation time: three dimensional mapping group and conventional treatment group were (48 ±16) min, (47±13) min, there was no significant difference. The patients in two groups of patients were successfully ablated; after 6 months of follow-up, three-dimensional mapping group had no recurrence, the conventional treatment group there was 1 case of recurrence, measurement system under the guidance of successful ablation in the Ensite Navx 3D standard, the two groups had no significant difference in overall success rate. Complications: no complications occurred in the two groups during rfa. CONCLUSION The application of Ensite Navx mapping guided radiofrequency catheter ablation is safe and effective for the treatment of AVNRT and does not increase the operation time nor complications, X-ray exposure time, exposure dose significantly reduced.