Abstract: AIM:To explore the clinical characteristics and cardiac function evaluation in patients with diastolic heart failure (DHF) and systolic heart failure (SHF). METHODS: A total of 253 patients with heart failure were selected including 118 DHF cases and 135 SHF cases, and 50 cases confirmed without organic heart disease served as control. Clinical data of patients were recorded and the differences of clinical characteristics between groups were analyzed. NT-proBNP and hs-CRP were detected in all patients. RESULTS: Both DHF and SHF were more common in elderly patients, but DHF was more common in females (56.8%). There were more patients with hypertension (81.4%) or atrial fibrillation (26.3%) in DHF group than in SHF group (P<0.01; P<0.05, respectively) and patients accompanied with CHD (45.8%) in DHF were less than those in SHF (P<0.01). Compared with those in the control group, NT-proBNP and hs-CRP in both DHF group and SHF group were significantly higher (P<0.01), but NT-proBNP in DHF group was lower than that in the SHF group (P<0.01). No significant difference was found in Hs-CRP between groups. CONCLUSION: DHF is more common in elderly females, which is often accompanied by hypertension or atrial fibrillation. NT-proBNP and hs-CRP can be used as indicators of the evaluation of heart failure both in DHF and in SHF.