Abstract: AIM:To analyze congenital heart deformity and hemodynamic data of Down syndrome. METHODS: Clinical data of Down’s syndrome with congenital heart disease and its hemodynamics were analyzed in 36 patients diagnosed with congenital heart disease patients with Down syndrome by transthoracic two-dimensional echocardiography, color Doppler flow imaging and right heart catheterization or angiocardiography from July 2008 to October 2012. RESULTS: Among the 36 cases, there were ten patients with VSD, six patients with AVSD, six patients with PDA, two patients with ASD, two cases with ASD+PDA, one case with ASD+VSD, one patient with ASD+PDA+VSD, four patients with VSD+PDA, one patient with PDA+BAV, two patients with TOF 2, and once patient with TOF+ASD. Eighteen patients had pulmonary hypertension including five cases of resistant pulmonary arterial hypertension. CONCLUSION: In cardiovascular malformations with Down syndrome, VSD (28%), AVSD (17%) and PDA (17%) are most common and are often associated with ASD or TOF. In patients without pulmonary artery stenosis, about half are complicated with pulmonary artery hypertension.