Abstract: AIM To investigate the correlation between serum platelet-derived growth factor and angiotensin II (AngII) in patients with acute coronary syndromes (ACS) and its significance. METHODS A total of 132 patients with acute coronary syndromes were enrolled in our hospital, which included 40 patients with unstable angina pectoris (UAP), 54 patients with non-ST segment elevation myocardial infarction (NSTEMI), and 38 patients with ST-segment elevation myocardial infarction (STEMI). Enzyme-linked immunosorbent assay serum levels of platelet-derived growth factor were measured and the levels of serum AngII were measured by radioimmunoassay. Statistical analysis was performed. RESULTS The levels of PDGF and AngII in peripheral blood of patients with acute coronary syndrome were significantly different between groups (P<0.05). Correlation analysis showed that PDGF was positively correlated with AngII in the peripheral blood of patients with acute coronary syndrome (r=0.413, P<0.05), and there was a significant positive correlation with the global registry for acute coronary events (GRACE) score (r=0.527, P<0.05). CONCLUSION With develepment of coronary heart disease, PDGF expression levels increase. PDGF is closely related to ACS GRACE score and AngII levels and might be a potential new indicator which could be utilized in the assessment of ACS risk stratification and prognosis.