Abstract: AIM: To explore the effect of low-dose anti-anxiety medication in the treatment of coronary heart disease (CHD) in patients with both CHD and anxiety disorders. METHODS: Forty cases of CHD and anxiety disorder were randomly divided into treatment group and conventional group. In addition to the conventional treatment, patients in the treatment group were given low-dose anti-anxiety medication. Four weeks after treatment, the occurrence of angina pectoris, ECG improvement and anxiety symptom assessment were compared between groups. RESULTS: Under the same workload, the occurrence of angina pectoris was significantly reduced in both groups and the total effective rate in the treatment group was 96%, whereas that in the conventional group was 79%, with significant difference between groups (P<0.05). No significant difference was observed in the effective rate of ECG between groups (treatment group 84% vs. conventional group 85%). After treatment, SAS scores in both groups declined, but significant differences were only found in the treatment group (P<0.05). The SAS scores in the treatment group were significantly lower than in the conventional group (P<0.05), demonstrating that anxiety symptoms in the treatment group were significantly more improved in the treatment group. CONCLUSION: Low-dose anti-anxiety drugs significantly reduce the occurrence of angina pectoris, effectively alleviate anxiety symptoms and improve the quality of life in patients with both CHD and anxiety disorders.