Abstract: AIM: To investigate the platelet reactivity in patients with coronary heart disease (CHD). METHODS: One hundred stable angina patients were given aspirin (100 mg, once daily) for 7 days. Thromboxane B2 (TXB2), 6-keto-prostaglandin F1α (6-6-keto-PGF1α), D-dimer (D-D), fibrinogen (FIB), homocysteine (HCY), and C-reactive protein (CRP) levels were then measured. The platelet reaction was measured by thrombelastograph (TEG). Patients were divided into high-platelet reaction groups (HPR) and low-platelet reaction groups (LPR). RESULTS: Platelet reactions were normally distributed. Females and patients with diabetes had higher platelet reactivity compared with males (52% vs. 28%, P<0.05) and patients without diabetes (64% vs. 32%, P<0.05). The prothrombotic status marker TXB2 ［(102±17) ng/L vs.(74±17) ng/L, P<0.05］ and CRP ［(7.7±1.6) mg/L vs.(4.3±1.2) mg/L, P<0.05］ were higher in HPR patients. CONCLUSION: Platelet reactivity in CHD patients has demonstrated some individual differences.