Abstract: AIM: To study the effect of aerobic exercise on serum soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cellular adhesion molecule-1 (sVCAM-1) and C-reactive protein (CRP) in patients with acute coronary syndrome (ACS). METHODS: Seventy patients with ACS were divided into two groups: regular treatment group and regular treatment plus aerobic exercise group. Healthy subjects were chosen as the control group. Levels of sICAM-1 and sVCAM-1 were tested by ELISA and the level of CRP was tested by immune turbidimetry. The results were compared. RESULTS: The levels of sICAM-1, sVCAM-1 and CRP in ACS patients were significantly higher than those in the control group (P<0.01). After treatment, the level of sICAM-1, sVCAM-1 and CRP decreased (P<0.05 and P<0.01), especially in the treatment plus aerobic exercise group (P<0.05 and P<0.01). CONCLUSION: The level of sICAM-1, sVCAM-1 and CRP increase in patients with ACS. Aerobic exercise markedly decreases the levels of sICAM-1, sVCAM-1 and CRP.