Abstract: AIM:To study plasma ghrelin level distribution in patients with coronary heart disease (CHD) with abnormal glucose metabolism and to discuss its clinical significance. METHODS: According to laboratory examination results, subjects were divided into control group, coronary heart disease with normal glucose metabolism group, coronary heart disease with abnormal glucose metabolism group and abnormal glucose metabolism group. Fasting blood samples were collected the morning after admission with EDTA-2K anticoagulation tubes. Blood samples were then transferred to centrifuge tubes containing aprotinin and were centrifuged to extract plasma for cryopreservation. All blood plasma ghrelin levels were tested with ELISA. RESULTS: Compared with those in control group, ghrelin levels were significantly reduced in the group with CHD with normal glucose metabolism, group of CHD with abnormal glucose metabolism and group with abnormal glucose metabolism. Compared with those in the group of CHD with normal glucose metabolism, levels of ghrelin were significantly reduced in patients with CHD with abnormal glucose metabolism. Using CHD and abnormal glucose metabolism as two factors affecting plasma ghrelin levels, factorial analysis showed no interaction (P=0.453). However, the group of abnormal glucose metabolism had more effect on plasma ghrelin levels than CHD. CONCLUSION: Ghrelin levels decreased significantly in patients with CHD with abnormal glucose metabolism and abnormal glucose metabolism has more obvious effects on ghrelin levels.