Abstract: AIM:To investigate the effects of degradable magnesium alloy stent with heparin and basic fibroblast growth factor (bFGF) implanted into transmural channels on myocardial revascularization after acute myocardial infarction. METHODS: Eighteen mini-swines were used to comprise the animal model by ligating the middle third of the left anterior descending (LAD). Animals were randomly divided into three groups: control group (A group, n=6), transmyocardial drilling revascularization (TMDR)+magnesium alloy stent with heparin group (B group, n=6) and TMDR+magnesium alloy stent with heparin and bFGF implantation group (C group, n=6). In groups B and C, two 2-mm diameter transmural channels were established using a self-made drilling device, followed by implantation of two stents into the channels in the two groups. Quantitative analysis of new vessels was performed by Image Pro Plus software 6 weeks postoperatively. The mass defect percent of myocardial perfusion was calculated by Emory Cardiac Toolbox software, and LVEDD, LVESD and LVEF reflective of cardiac functions were measured by echocardiology at pre-treatment and 6 weeks post-treatment. RESULTS: Six weeks postoperatively, both LVEF and mass defect percent in B group and C group showed significant differences compared with those in A group (P<0.05). New vessel density significantly increased in C group compared with that in A and B groups (P<0.01). CONCLUSION: Degradable magnesium alloy stent with heparin and bFGF increases new vessel density and improves myocardial perfusion, thus enhancing cardiac functions.