Abstract: AIM:To evaluate the feasibility of diagnosing coronary stenosis and myocardial ischemia with a single dualenergy CT (DSCT) acquisition method. METHODS: Sixty patients underwent dualsource dual energy CT and conventional coronary angiography (CAG). CAG results served as the “gold standard” to evaluate the diagnosis of coronary artery disease (CAD) and stenosis ≥50% (positive). We assessed the sensitivity, specificity and concordance rate of DSCTA plus DSCTP (parallel trial) in diagnosis of CAD. RESULTS: Sensitivity of DSCTA was 84%, specificity was 93%, and concordance rate was 89%. Combination of DSCTA and DSCTP (parallel trial) resulted in a sensitivity of 94%, specificity of 91%, and concordance of 92%. Compared with DSCTA, sensitivity and concordance is slightly improved, whereas there was a slight decrease in specificity but without reaching significance. CONCLUSION: DSCTA plus DSCTP provide a high diagnosis for CAD. DSCTA plus DSCTP with DSCTA shows no significant difference in the diagnostic value.