Abstract: AIM To investigate the differences of lung ultrasound in different types of heart failure and to analyze the correlation between lung ultrasound and other indexes. METHODS 124 consecutive acute heart failure patients were divided into two groups, including preserved ejection fraction heart failure (HFpEF) and reduced ejection fraction heart failure (HFrEF). To compare differences of the two groups in clinical data and cardiopulmonary ultrasound measurements, additional investigation was performed to evaluate whether there was a difference in correlating between B lines with N-terminal pro brain natriuretic peptide (NT-proBNP)、E/e’, left ventricular ejection fraction (LVEF) in the two types of heart failure. RESULTS There was no significant difference in clinical data between HFpEF and HFrEF groups. The LVEF and interventricular septal thickness of the HFpEF group were significantly higher than that of the HFrEF group, but the left ventricular end-diastolic diameter, end-systolic diameter and inferior vena cava diameter were significantly smaller than that of HFrEF group. B lines had no significant differences between the two groups, The correlation between B lines and E/e’ was better than NT-proBNP in HFpEF group (r=0.886, r=0.755), and the correlation between B lines and NT-proBNP was better than E/e’ in the HFrEF group (r=0.829, r=0.737). CONCLUSION There was a significant positive correlation between B lines and NT-proBNP, E/e’, regardless of HFpEF or HFrEF.