Abstract: AIM To analyze the correlation of hyperuricemia (HUA) and metabolic syndrome (MetS) components. METHODSA total of 2778 subjects who underwent physical examination in the First Affiliated Hospital of Xinjiang Medical University in 2014 were divided into HUA group (593 cases) and normal uricemia group (2185 cases) according to the diagnostic criteria of hyperuricemia. Clinical data and biochemical indices were collected and statistical analysis was conducted. RESULTSUnivariate analysis of hyperuricemia showed that the distribution of gender, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), triglyceride (TG), high-density lipoprotein (HDL-C), fasting plasma glucose (FPG) and MetS in HUA group was significantly different from that in normal uricemia group (P<0.01). Logistic regression indicated that overweight/obesity, hypertension, higher levels of TG, lower level of HDL-C and MetS were factors correlative of HUA (P<0.01). CONCLUSIONHyperuricemia is closely related to components of MetS. Pearson correlation suggests that hyperuricemia was negatively correlated with high-density lipoprotein (HDL-C) (r=-0.195, P<0.01).