Abstract: Hypertension is one of the most common cardiovascular disease risk factors and angiotensin II receptor blockers (ARB) are antihypertensive drugs acting on the renin-angiotensin-aldosterone system. In recent years, ARB drugs have been widely used in the clinical setting. This article analyzes the reasons why ARB drugs are clinically used as the first-line antihypertensive drugs by discussing the protective role of ARB for target organs such as in cardiovascular, cerebrovascular, and kidney diseases as well as diabetes.