田倪妮, 魏 玲, 李宏键, 陈 黔, 倪茂娥, 马 玲, 林梦娇. 热休克蛋白47与PⅠCP在慢性心力衰竭患者中的相关性[J]. 心脏杂志, 2015, 27(1): 45-047.
    引用本文: 田倪妮, 魏 玲, 李宏键, 陈 黔, 倪茂娥, 马 玲, 林梦娇. 热休克蛋白47与PⅠCP在慢性心力衰竭患者中的相关性[J]. 心脏杂志, 2015, 27(1): 45-047.
    shu
    Correlation between heat shock protein 47 and pro-collagen type I C-terminal peptide in patients with chronic heart failure[J]. Chinese Heart Journal, 2015, 27(1): 45-047.
    Citation: Correlation between heat shock protein 47 and pro-collagen type I C-terminal peptide in patients with chronic heart failure[J]. Chinese Heart Journal, 2015, 27(1): 45-047.
    shu

    热休克蛋白47与PⅠCP在慢性心力衰竭患者中的相关性

    Correlation between heat shock protein 47 and pro-collagen type I C-terminal peptide in patients with chronic heart failure

      摘要
    • 摘要: 目的:慢性心力衰竭（CHF）是一种慢性的，逐渐进展的临床综合征。研究热休克蛋白47(HSP47)与血清Ⅰ型胶原羧基端肽(PⅠCP)在CHF不同心功能分级中的表达及其相关性。方法： 将60名患者分为心功能Ⅰ级、心功能Ⅱ级、心功能Ⅲ级，采用ELISA测定患者血清中的HSP47的含量与PⅠCP的含量，并研究两者与CHF的相关性。结果： 与心功能1级组比较，心功能Ⅱ级组PⅠCP含量显著增高（P<0.01），且心功能Ⅲ级组较心功能Ⅱ级组PⅠCP含量显著增高（P<0.01），且血清HSP47含量与PⅠCP含量呈正相关。结论： CHF患者存在心肌纤维化及左心室扩大，两者呈正相关关系，提示CHF患者存在心室结构重构，心肌纤维化在心室重构中起重要作用。CHF患者HSP47和PⅠCP显著升高，且呈显著正相关。

       

      Abstract: AIM:To study the correlation between heat shock protein 47 and pro-collagen type I C-terminal peptide (PICP) in patients with different classifications of chronic heart failure (CHF). METHODS: Sixty patients were equally divided into three groups: NYHA I group, NYHA II group, and NYHA III group (n=20 in each group). Expressions of HSP47 and PICP in serum were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: Serum concentration of PICP in the NYHA II group was significantly higher than in the NYHA I group and the concentration of serum PICP in NYHA III group was significantly higher than in the NYHA II group (both P<0.05). A positive correlation was found between expression of HSP47 and PICP. CONCLUSION: Myocardial fibrosis and left ventricular diameter are positively correlated, suggesting that myocardial fibrosis plays an important role in ventricular remodeling. HSP47 and PICP in blood-serum have a significantly positive correlation in patients with CHF.

       

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