Abstract: AIM:To compare the stability, accuracy and correlation between two common noninvasive central aortic pressure gauges (A-PULSE CASPro and SphygmoCor) in measuring central aortic systolic pressure. METHODS: Four hundred and fifty male volunteers, aged 19-23 years with an average of (22±1), were enrolled in this study. After medical history was acquired, basic data was recorded and the volunteers signed the informed consent, the right brachial artery blood pressure was measured after 10 minutes’ sitting rest. Then, A-PULSE CASPro and SphygmoCor were used separately to measure the central aortic systolic pressure and the data were recorded. RESULTS: The mean absolute deviation of the central aortic systolic pressure value measured by A-PULSE CASPro and SphygmoCor was 1.57 mmHg and the standard deviation was 2.53 mmHg. The linear regression equation of the two instruments was Y=0.9231*X+9.9341. Good consistency of the central aortic systolic pressure value was obtained by both A-PULSE CASPro and SphygmoCor, with the value of R2=0.9123. CONCLUSION: The central aortic systolic pressure values measured by both A-PULSE CASPro and SphygmoCor are matched. The errors of the two instruments with the evaluation of Bland-Altman are within the range of (5±8) mmHg. The predictive indication of the central aortic systolic pressure is more obvious than that of the peripheral systolic pressure in forecasting the cardiovascular events. Noninvasive central blood pressure measurement has important clinical value in the diagnosis of hypertension and blood pressure management.