Abstract: Interaction between heart failure and liver has not been fully demonstrated, although some studies have proven that heart failure can induce liver injury. Cardiogenic liver injury presents abdominal distension, intermittent right upper quadrant discomfort, nausea and anorexia, which are often misdiagnosed as gastrointestinal disease. The effect of cardiogenic liver injury on heart failure is often neglected. The biomarkers of liver damage (bilirubin, GGT and albumin) can predict the severity and prognosis of heart failure independently. Cardiogenic liver injury influences the hepatic clearance of drugs and early management of cardiogenic liver injury can improve the symptoms and prognosis of heart failure and lower mortality.