β3肾上腺素能受体与心房颤动心肌代谢重构的研究进展

Research progress of β3 adrenergic receptor and myocardial metabolic remodeling of atrial fibrillation

摘要: 心房颤动（atrial fabrillation，AF）时，心房发生代谢重构，可促进AF的发生及维持，二者相互促进形成恶性循环，可进一步加重AF。研究表明β3肾上腺素能受体（β3-Adrenoceptor，β3-AR）与AF电重构、结构重构密切相关，但关于β3-AR对AF心肌能量代谢重构作用的报道较少。本综述旨在探讨β3-AR与AF心肌能量代谢重构的关系，为临床AF的防治寻找新靶点。

Abstract: With atrial fibrillation (AF), metabolic remodeling can occur in the atrium and promote the occurrence and persistence of AF. The two mutually promote, forming a vicious spiral, further aggravating the AF. Research shows that β3 adrenergic receptor (β3-AR) is closely related to the myocardial electrical remodeling and structural remodeling of AF, but there have been relatively few reports concerning the effect of β3-AR on myocardial energy metabolism remodeling of AF. This review explores the relationship between β3-AR and myocardial energy metabolism remodeling of AF in order to find new targets for clinical treatment of AF.