Abstract: In addition to directly protecting the heart, granulocyte colony-stimulating factor (G-CSF) also exerts some indirect protective effects on accelerating repair and reducing adverse cardiovascular events by stimulating the bone marrow to mobilize the stem cell to the peripheral blood. In recent years a large number of clinical studies have been performed to detect the effect of G-CSF on cardiovascular diseases. The dosage of G-CSF, time of use, duration of treatment and combined therapy with other drugs may all influence the outcomes. In this article we summarize the clinic research results at home and abroad to provide more information for the further study of G-CSF and cardiovascular diseases.