血小板源性生长因子及其受体在心血管疾病中的作用

Roles of platelet-derived growth factors and platelet-derived growth factor receptors in cardiovascular diseases

摘要: 血小板源性生成因子（PDGFs）及其受体（PDGFRs）在心血管疾病中发挥着重要作用，二者不仅参与了动脉粥样硬化（AS）的形成，而且在血管生成、心肌纤维化过程中也扮演了重要角色。PDGFRs被其配体PDGFs激活后，在血管平滑肌细胞、纤维母细胞、内皮细胞等中的表达上调，通过细胞内信号转导通路，促使该类靶细胞增殖分化，从而参与AS、血管生成和心肌纤维化的发生。本文就PDGFs/PDGFRs在心血管疾病中的研究进展做一综述。

Abstract: Platelet-derived growth factors (PDGFs) and platelet-derived growth factor receptors (PDGFRs) both play some important roles in the cardiovascular diseases, including atherosclerosis (AS), angiogenesis and myocardial fibrosis. PDGFRs which are activated by their ligand PDGFs up-regulate in cells, such as vascular smooth muscle cells, fibroblasts and endothelial cells, thus resulting in the proliferation and differentiation of target cells. PDGFs/PDGFRs participate in AS angiogenesis and myocardial fibrosis. This review will discuss the research progress of PDGFs/PDGFRs in the cardiovascular diseases.