马丽娜, 冯明, 马佳, 周英智, 黄萍. 老年高血压病并发非酒精性脂肪肝的相关影响因素[J]. 心脏杂志, 2010, 22(3): 373-375.
    引用本文: 马丽娜, 冯明, 马佳, 周英智, 黄萍. 老年高血压病并发非酒精性脂肪肝的相关影响因素[J]. 心脏杂志, 2010, 22(3): 373-375.
    Association between elderly hypertensive subjects and nonalcoholic fatty liver[J]. Chinese Heart Journal, 2010, 22(3): 373-375.
    Citation: Association between elderly hypertensive subjects and nonalcoholic fatty liver[J]. Chinese Heart Journal, 2010, 22(3): 373-375.

    老年高血压病并发非酒精性脂肪肝的相关影响因素

    Association between elderly hypertensive subjects and nonalcoholic fatty liver

    • 摘要: 目的: 探讨老年原发性高血压(EH)并发非酒精性脂肪肝(NAFLD)的相关影响因素。方法: 将90例老年高血压病患者分成2组,NAFLD组40例,非NAFLD组50例,比较两组间体质量指数(BMI)、腰臀比(WHR)、总胆固醇(TC)、三酰甘油(TG)、C反应蛋白(CRP)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、血肌酐(Cr)和空腹血糖(FPG)的差异,并进行Logistic回归分析。结果: NAFLD组与非NAFLD组在BMI(26.8±2.3与22.6±2.4,P<0.01)、WHR(0.96±0.03与0.91±0.04,P<0.01)、TG[(2.6±0.4)mmol/L与(2.0±0.5)mmol/L,P<0.01]、HDL-C[(1.5±0.3)mmol/L与(1.7±0.4)mmol/L,P<0.01]、ALT[(31±8)mmol/L与(26±7)mmol/L,P<0.05]、AST[(28±7)mmol/L与(24±7)mmol/L,P<0.05]、FPG[(5.2±0.8)mmol/L与(4.8±0.7)mmol/L,P<0.01]的差异有统计学意义,Logistic回归分析显示BMI(P<0.01)、WHR(P<0.01)和TG(P<0.01)是高血压病并发NAFLD的独立影响因素。结论: BMI、WHR和TG是高血压并发NAFLD的独立危险因素。

       

      Abstract: AIM: To explore the associated factors between essential hypertension (EH) and nonalcoholic fatty liver (NAFLD) in elderly patients. METHODS: Ninety elderly hypertensive patients were divided into two groups: EH co-existing with NAFLD group (n=40) and group of patients with EH without NAFLD (n=50). Body mass index (BMI), waist/hip ratio (WHR), total cholesterol (TC), triglycerides (TG), C-reactive protein (CRP), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine (Cr) and fasting plasma glucose (FPG) were compared between groups and logistic regression was analyzed. RESULTS: In the group of EH co-existing with NAFLD, levels of BMI (26.8±2.3 vs.22.6±2.4, P<0.01), WHR (0.96±0.03 vs. 0.91±0.04, P<0.01), TG [(2.6±0.4) mmol/L vs.(2.0±0.5) mmol/L, P<0.01], ALT [(31±8) mmol/L vs.(26±7) mmol/L, P<0.05], AST [(28±7) mmol/L vs.(24±7) mmol/L, P<0.05], and FPG [(5.2±0.8) mmol/L vs.(4.8±0.7) mmol/L, P<0.01] were higher than in the EH without NAFLD group, whereas HDL-C [(1.5±0.3) mmol/L vs.(1.7±0.4) mmol/L, P<0.01] was lower than in the EH without NAFLD group. Logistic regression showed that BMI (P<0.01), WHR (P<0.01) and TG (P<0.01) were independent factors. CONCLUSION: BMI, WHR and TG are independent factors of EH co-existing with NAFLD in elderly patients.

       

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