Abstract: AIM To evaluate the role of routine delayed percutaneous coronary intervention (PCI)after thrombosis in the management of patients with STsegment elevation myocardial infarction (STEMI). METHODS Thirty-eight patients with STEMI who underwent routine delayed PCI after thrombosis (therapy group)and 34 patients with STEMI who were given conservative strategy after thrombosis (control group) were enrolled in this study and were compared in major adverse clinical events (MACE)and cardiac structure and function by echocardiography during hospitalized period and 6month followup. RESULTS Compared with conservative strategy after thrombosis, routine delayed PCI after thrombosis decreased the inhospital mortality (0% vs 15%), shortened the average hospital stay time (15 d vs 28 d), prevented recurrent angina (5% vs 35%)and reinfarction (0% vs 9%), produced lower mortality (3% vs 12%)and rehospitalization (8% vs 26%) during the followup period and prevented further left ventricle remodeling. CONCLUSION Routine delayed PCI after thrombosis may prevent MACE and improve immediate results and 6month prognosis of patients with STEMI.