冠心病与睡眠呼吸暂停综合征关系的Meta分析

侯 扬; 孙晓斐

冠心病与睡眠呼吸暂停综合征关系的Meta分析

侯扬,
孙晓斐

A meta-analysis on the relationship between sleep apnea syndrome and coronary artery disease

摘要

摘要: 目的:通过Meta分析有关冠心病与睡眠呼吸暂停综合征（sleep apnea syndrome,SAS）关系的病例对照研究的文献，为冠心病与SAS相互关系的研究提供循证医学的证据。方法：收集和整理有关冠心病与SAS关系的病例对照研究的文献，观察对比冠心病和非冠心病患者群中SAS的发生率，用RevMan 5.2分析软件、Stata12SE分析软件对纳入的研究进行异质性检验和合并分析，结果以比数比（odds ratio，OR）表示，计算95%可信区间（95%CI），评估发表性偏倚和敏感性检验。结果：纳入的14组研究根据SAS定义不同分为两组分析，分析前9项研究显示OR=2.95,95%CI(2.25-3.87)，P<0.05，差异有统计学意义；后5项研究R=3.42, 95%CI(1.74-6.71)，P<0.05，差异有统计学意义，表示SAS发生率与冠心病具有正的关联性，经检验不存在发表偏倚且敏感度分析示稳定度较高。结论：冠心病患者群中SAS的发生率高于非冠心病患者，SAS是冠心病的危险因素。

Abstract: AIM:To analyze case-control studies on the relationship between coronary artery diseases (CAD) and sleep apnea syndrome (SAS) and to provide support of evidence-based medicine for studies regarding SAS and CAD. METHODS: Literature reports of case-control studies on the relationship between CAD and SAS were collected and the morbidity of SAS in CAD group and non-CAD group was compared. Heterogeneity and original data were analyzed by Stata12 and RevMan5.2 and the outcomes were indicated by OR and 95% CI. Publication bias and sensitivity were also tested. RESULTS: Selected studies were categorized into two groups according to different definitions of SAS. The outcomes of the first group with nine studies were statistically significant (OR=2.95, 95% CI 2.25-3.87, P<0.05) and the outcomes of the second group with five studies were also statistically significant (OR=3.42, 95% CI 1.74-6.71, P<0.05). Bias test showed no publication bias and sensitivity analysis showed that the results were stable. The morbidity of SAS showed a positive correlation with CAD. CONCLUSION: The morbidity of SAS in CAD patients is higher than in patients without CAD. SAS is a risk factor for CAD.

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