Abstract: AIM: To study the clinical characteristics and pathological changes in coronary artery in patients with recurrent myocardial ischemia after coronary artery bypass grafting (CABG). METHODS: Data were retrospectively reviewed in 247 patients who had recurrent myocardial ischemia after CABG and underwent percutaneous coronary intervention (PCI). Patients were divided into two groups: diabetes mellitus (DM) group and non-DM groups. RESULTS: The ratio of recurrent myocardial ischemia was higher and PBG and HbAl were significantly higher in DM group (P<0.05). A significant difference was observed in blood vessel changes and types of PCI stent (P<0.05). Long-term ratio of the AMI was higher in DM group (11.9%) compared with that in non-DM group (5.1%) (P<0.05) and the revascularization rate was also higher in DM group (22.4%) than the rate (15.3%) in non-DM group (P<0.05). CONCLUSION: Recurrent myocardial ischemia after CABG is high in patients with diabetes mellitus along with severe coronary vessel involvement and complications.