Abstract: AIM:To analyze and discuss of the clinical effect and experience of surgical treatment for Kawasaki coronary disease. METHODS: Clinical data of 13 patients with Kawasaki coronary artery disease from January 2004 to December 2012 were analyzed retrospectively. All patients underwent coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) in eight patients and off-pump technique in five patients. Left internal mammary artery was used in all cases. The combined procedures included coronary aneurysmectomy in two patients, coronary artery thrombus removal in one case, and mitral valve replacement in one case. RESULTS: One 4-year-old patient died of low cardiac output syndrome and acute renal failure 19 days after operation and who underwent CABG, coronary aneurysmectomy and coronary artery thrombus removal. The age of surgical operation was 3-49(18.5±13.5) years old. All patients had serious coronary stenosis or occlusion or reversible ischemia. Cardiopulmonary bypass and aortic clamp were 41-455(137±136) min and 18-117(50±37) min, respectively. The mean number of grafts was 1-3(2.1±0.8) and all patients except one<18 years old used artery graft. During the follow-up ranging from 3 months to 6 years, clinical symptoms were alleviated or disappeared. The diameter of the coronary aneurysm decreased. CONCLUSION: CABG is an effective procedure for Kawasaki CAD, which requires no treatment of coronary aneurysm at the same time.