低声压级水平次声对心肌梗死大鼠心肌纤维化的影响及机制研究

吴敬国; 梁艳冰; 唐皓; 裴兆辉; 庄志强; 马虹; 马中富

低声压级水平次声对心肌梗死大鼠心肌纤维化的影响及机制研究

Effects of low-decibel infrasound on cardiac fibrosis of rats with acute myocardial infarction and underlying mechanism

摘要

摘要: 目的: 观察次声对心肌梗死后大鼠心肌纤维化的影响及相关机制研究。方法: 将30只SD大鼠随机分为3组，即假手术组、心肌梗死组及次声治疗组，每组10只。采用低声压级水平次声对心肌梗死大鼠治疗1周（2次/d，0.5 h/次），观察心肌胶原和血浆NO和血管紧张素-Ⅱ（AngⅡ）及大鼠心功能的变化。结果: 与心肌梗死组大鼠比较（未治疗组），次声治疗组大鼠心肌胶原表达明显减少，血浆NO含量显著增加（P<0.01），血浆AngⅡ含量显著降低（P<0.01），心功能明显改善（P<0.01）。结论: 低声压级水平次声治疗能够明显减轻心肌梗死后大鼠心肌纤维化，其作用可能与血浆NO及AngⅡ含量变化有关。

Abstract: AIM: To observe the changes of cardiac fibrosis and its underlying mechanism after acute myocardial infarction in rats. METHODS: Thirty male Sprague Dawley rats were randomized to control group, infarction group and infrasound treatment group (10 rats/group). Rats in the infrasound treatment group were treated with infrasound for 7 days, 0.5 h, twice/day. Collagen expression of rat myocardium and contents of NO and Ang-II in rat plasma and rat heart function were observed. RESULTS: Compared with those in the infarction group, the collagen expression of rat myocardium increased in the infrasound treatment group (P<0.01), the contents of NO in rat plasma significantly decreased (P<0.01), the contents of ET-1 in rat plasma significantly increased (P<0.01), and heart function was significantly improved. CONCLUSION: Infrasound treatment significantly assuages the cardiac fibrosis of rats after myocardial infarction, which may be relative with the changes of NO and Ang-II.

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