Abstract: Oxidative stress, inflammation and apoptosis play an important role in myocardial ischemia reperfusion injury (MI/RI). There is a close relationship between protease activated receptor-2 (PAR-2) and MI/RI. PAR-2 is widely distributed in the cardiovascular system, which may be activated by many proteases and result in a variety of biological effects. This article aims to explore the relationship from the above aspects and to provide a theoretical basis for prevention and treatment of MI/RI.