Abstract: AIM: To explore a better therapy program for hypertensive patients with left ventricular diastolic dysfunction. METHODS: Sixty hypertensive out-patients were randomly divided into three groups: Group 1 treated with levamlodipine besilate (5 mg) nightly, Group 2 treated with enalapril maleate (10 mg) twice daily, and Group 3 treated with levamlodipine besilate (2.5 mg) nightly plus enalapril maleate (5 mg) twice daily. LVEF, IVRT, E/A, and side effects were recorded before treatment and 6 months after treatment. RESULTS: LVEF of the three groups before and after treatment showed no significant differences. IVRT and E/A improved significantly (P<0.05). After treatment, LVEF and IVRT showed no significant difference among the three groups. Compared with that in Group 1 and Group 2, Group 3 E/A was significantly different (P<0.05). CONCLUSION: In the treatment of hypertensive patients with diastolic dysfunction, levamlodipine besilate and enalapril maleate improve the indicator of diastolic function. The combination of low-dose levamlodipine besilate and enalapril maleate significantly improves the E/A with few side effects.