Abstract: AIM:To investigate the relations between the levels of blood uric acid (UA) and serum homocysteine (HCY) and the severity of coronary artery lesions in patients with coronary heart disease (CHD). METHODS: Patients were divided into CHD group (165 cases) and normal control group (54 cases) depending on the results of the coronary angiography. According to Gensini scores, we subdivided the CHD group into three groups: Group A (<20 points), Group B (20-40 points) and Group C (>40 points). The concentrations of blood uric UA and serum HCY were compared among groups. RESULTS: The levels of blood UA and serum homocysteine HCY in CHD groups were obviously higher than those in normal control group (P<0.05), with statistically significant difference between groups with different Gensini scores (P<0.05). CONCLUSION: Concentrations of blood UA and serum HCY are closely related to the severity of coronary artery lesions and can be a severity predictor of coronary artery lesions.