Abstract: AIM To investigate the effects of bisoprolol on brain natriuretic peptide (BNP) in patients with hypertension combined with chronic heart failure (CHF) and to provide a theoretical basis for the formulation of clinical treatment. METHODSOne hundred and two hypertensive patients combined with CHF in our hospital were randomly divided into observation group and control group (51 cases in each group). The control group received conventional treatment and the observation group received conventional treatment plus bisoprolol. After 3 months of treatment, improvement of heart function of the two groups was compared and changes of heart rate, blood pressure, left ventricular ejection fraction and BNP before and after treatment were also compared between groups. RESULTSThe total effective rate in the observation group was 96.08%, significantly higher than in the control group (P<0.05). In both groups, heart rate, systolic blood pressure and diastolic blood pressure were significantly lower, whereas left ventricular ejection fraction was significantly higher than before treatment (P<0.05). Left ventricular ejection fraction in observation group was significantly higher than in control group. BNP levels in both groups decreased markedly after treatment (both P<0.05) and the level in the observation group was significantly lower than the control group (P<0.05). CONCLUSIONBisoprolol can effectively reduce the level of BNP in hypertensive patients combined with CHF, promote curative effects and improve heart function.