冠心病患者血清缺氧诱导因子-1α与血管内皮生长因子水平的变化
Changes of serum hypoxia-inducible factor-1α and vascular endothelial growth factor in patients with coronary heart disease
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摘要: 目的: 研究冠心病(CHD)患者血清血管内皮生长因子（vascular endothelial growth factor，VEGF）和低氧诱导因子-1α（hypoxia inducible factor 1α,HIF-1α）水平的变化意义。方法: CHD患者79例，分为急性冠脉综合征(ACS)组42例，稳定型心绞痛（SAP）组37例，另选35例作为对照组，所有患者清晨空腹抽血应用ELISA法测定VEGF和HIF-1α水平。结果: ACS组VEGF和HIF-1α水平显著高于SAP组和对照组(P<0.05);SAP组VEGF和HIF-1α水平与对照组比较差异无统计学意义。结论: VEGF和HIF-1α水平升高可能是冠状动脉粥样硬化斑块的不稳定的标志。Abstract: AIM: To study the serum level of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1α (HIF-1α) in patients with coronary heart disease (CHD) and to discuss their clinical significance. METHODS: Seventy-nine patients with CHD were chosen and divided into two group: acute coronary syndrome (ACS) group (n=42) and stable angina pectoris (SAP) group (n=37). Thirty-five healthy subjects were chosen as control group. Serum levels of VEGF and HIF-1α from fasting blood were tested in all patients using ELISA. RESULTS: Serum levels of VEGF and HIF-1α in ACS group were higher than those in SAP group and control group (P<0.05). No difference was observed in VEGF and HIF-1α between SAP and control group. CONCLUSION: Elevated levels of VEGF and HIF-1α may be signs of atherosclerotic plaque destabilization.
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