Abstract: AIM:To investigate the risk factors of acute cerebral infarction in type H hypertensive patients in Tongchuan City. METHODS: A 1∶1 matched case-control study was conducted in 561 cases of confirmed acute cerebral infarction diagnosed in H type hypertensive patients in Tongchuan City. EPI-info (6.04) and SPSS (15) were used for the logistic regression analysis of single and multiple factors, and the adjusted odds ratio of each factor (OR) and 95% confidence limit (CI) were calculated. RESULTS: Single factor analysis found that hyperlipidemia, diabetes, high C-reactive protein, transient ischemic attack (TIA), obesity, smoking and alcoholism were related to acute cerebral infarction. Enalapril maleate and folic acid tablets reduced the risk of acute cerebral infarction in H type hypertensive patients. Multivariate analysis showed that diabetes, high C-reactive protein, severe carotid stenosis and TIA were the main risks of acute cerebral infarction in H type hypertensive patients. CONCLUSION: The independent risk factors in H type hypertensive patients are high C-reactive protein, diabetes, severe carotid stenosis and TIA. Enalapril maleate and folic acid tablets are protective factors.