失功能性高密度脂蛋白致动脉粥样硬化的机制

Mechanism of dysfunctional high-density lipoprotein-induced atherosclerosis

摘要: 近几年的一些研究认为，在一些疾病中（如Ⅱ型糖尿病及代谢综合征及系统性红斑狼疮等），一直被誉为“好脂蛋白”的高密度脂蛋白（HDL）不仅血浆水平降低，其结构还会发生改变进而功能逆转，加速了动脉粥样硬化（AS）的发展，提高心血管病的风险。因此，阐明失功能性HDL在疾病状态中致AS的机制将有助于心血管疾病的预防与治疗，本文就功能性和失能性HDL的抗AS作用进行了综述。

Abstract: In recent years it has been found that high-density lipoprotein, hailed as “good LDL” in some studies, is reduced and its structure changes in some diseases such as type 2 diabetes, metabolic syndrome, and systemic lupus erythematosus. The reversed function accelerates the development of atherosclerosis and enhances risks of cardiovascular disease. This paper reviewed the anti-atherosclerosis mechanism of functional and dysfunctional high-density lipoprotein.