Abstract: Interleukin-33 (IL-33) is a new cytokine of the IL-1 and IL-33 families. When mediated by the receptor ST2, it has the effect of regulating immune and inflammatory, decreasing myocardial apoptosis, and inhibiting myocardial fibrosis as well as the formation and development of coronary atherosclerotic heart disease. IL-33 also reduces the risk of obesity. In this paper the roles of IL-33 in the formation of coronary heart disease, control of risk factors, and prognostic evaluation of coronary heart disease were reviewed.