转录因子FoxO1的修饰调节效应及在心血管疾病中的作用
Progress of transcription factor FoxO1 and its role in cardiovascular diseases
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摘要: FoxO1是FoxO亚家族中最早发现的转录因子,其转录活性受到多种蛋白修饰的调节。近年研究显示,FoxO1在多种心血管疾病的发生、发展中都发挥着重要作用。本文在此对FoxO1的修饰调节效应及其在心血管疾病中的作用作一综述。Abstract: FoxO1 is the first transcription factor found in FoxO subfamily. The transcriptional activity of FoxO1 is regulated by a variety of protein modifications. Recent studies have shown that FoxO1 plays an important role in the development of cardiovascular diseases. In this article, a review is presented of posttranslational modification effects on FoxO1 and its role in cardiovascular diseases.