郎立国, 李振军, 孙荣亮, 栾 红, 葛利军. 长期口服他汀类药物与急性ST段抬高型心肌梗死经皮冠状动脉介入治疗预后的相关性[J]. 心脏杂志, 2015, 27(4): 434-436.
    引用本文: 郎立国, 李振军, 孙荣亮, 栾 红, 葛利军. 长期口服他汀类药物与急性ST段抬高型心肌梗死经皮冠状动脉介入治疗预后的相关性[J]. 心脏杂志, 2015, 27(4): 434-436.
    shu
    Prognostic value of statins on 1-year major adverse cardiac events in ST-elevated myocardial infarction after percutaneous coronary intervention[J]. Chinese Heart Journal, 2015, 27(4): 434-436.
    Citation: Prognostic value of statins on 1-year major adverse cardiac events in ST-elevated myocardial infarction after percutaneous coronary intervention[J]. Chinese Heart Journal, 2015, 27(4): 434-436.
    shu

    长期口服他汀类药物与急性ST段抬高型心肌梗死经皮冠状动脉介入治疗预后的相关性

    Prognostic value of statins on 1-year major adverse cardiac events in ST-elevated myocardial infarction after percutaneous coronary intervention

      摘要
    • 摘要: 目的 探讨长期口服他汀类药物与急性ST段抬高型心肌梗死（STEMI）行急诊经皮冠脉介入（PCI）治疗患者预后的关系。方法 选择STEMI行急诊PCI患者301例，根据长期是否服用他汀类药物分为未服组(198例)和服用组(103例)。对患者随访1年，观察主要心脑血管不良事件（MACCE）发生率。并对各因素采用Logistic回归分析。结果 未服用组MACCE发生率〔50/198(25.3%)〕显著高于服用组〔14/103(13.6%)〕（P<0.05）,主要表现在再发心绞痛〔36/198(18.2%) vs. 7/103(6.8%)，P<0.01〕和再次住院〔40/198(20.2%) vs. 9/103(8.7%)，P<0.01〕。多因素Logistic回归分析示长期服用他汀类药物是一个保护因子（OR 0.24，95%CI 0.10-0.55，P<0.01）。结论 长期服用他汀类药物可降低STEMI行急诊PCI患者1年MACCE的发生率,是一个保护因子。

       

      Abstract: AIM To investigate the relationship between long-term statin pretreatment and 1-year major adverse cardiac events in patients with ST-elevated myocardial infarction (STEMI) after percutaneous coronary intervention (PCI). METHODS Three hundred and one STEMI patients were divided into group A (no long-term statin pretreatment, n=198) and group B (long-term statin pretreatment, n=103). Patients were followed-up for 1 year and clinical data and cardiovascular and cerebrovascular events (MACCE) were analyzed. The independent effect of variables on the prognosis was calculated using binary logistic regression analysis. RESULTS MACCE rate was higher in group A than in group B (P<0.05). This difference resulted from recurrent angina (P<0.01) and rehospitalization (P<0.01). In binary logistic regression analysis, long-term statin pretreatment was a protective factor in STEMI patients after PCI (OR 0.24, 95%CI 0.10-0.55, P<0.01). CONCLUSION Long-term statin pretreatment can reduce 1-year MACCE rate in STEMI patients after PCI and is a protective factor.

       

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