Abstract: AIM:To study the correlative factors of hyperamylasemia after cardiac surgery with cardiopulmonary bypass in patients without acute pancreatitis. METHODS: A retrospective analysis of 111 patients undergoing cardiac surgery with cardiopulmonary bypass was carried out. Patients were divided into non-hyperamylasemia group (<450 U/L, n=54) and hyperamylasemia group (≥450 U/L, n=57) according to the serum amylase level. There was no hospital mortality or postoperative abdominal complications in either group. Differences in ages, gender ratios, cardiopulmonary bypass time, blocking circulation time, serum creatinine levels, lactic acid, white blood cell count and oxygen indexes were compared. Analysis was done of the correlation of amylase and other levels. RESULTS: Except for the significant difference (P<0.05) in serum creatinine, no other obvious differences were found in age, gender, cardiopulmonary bypass time, blocking circulation time, white blood cell count and oxygen indexes between groups. However, there was no significant correlation between amylase level and other levels including serum creatinine. CONCLUSION: Amylase level after cardiac surgery with cardiopulmonary bypass had no significant correlation with other factors but may have had a correlation with creatinine.