Abstract: AIM:To study the effectiveness of transcatheter occlusion in patients with perimembranous ventricular septal defect (VSD) accompanied by tricuspid valve insufficiency (TI). METHODS: Fortytwo patients with perimembranous VSD accompanied by TI were included in the study. TI was caused by the bloodstream through ventricular septum impact tricuspid valve and chordae tendineae. Patients were randomly divided into two groups:group A (n=20) was treated with occluder implantation and group B was treated with surgery (n=22).The severity of TI, success rate of surgery, rate of complications, hospital stay after operation,total hospitalization expenses, mean operation time, inotropic score, white blood cell count,C-reactive protein and markers for serum myocardial damage in the two groups were compared. RESULTS:TI was alleviated after operation in both groups and no statistically difference in TI severity after operation was found between groups. Mean operation time, inotropic score, white blood cell count,C-reactive protein and markers for serum myocardial damage in group A were better than those in group B.Total hospitalization expenses in group A were lower than in group B and no statistically significant difference between groups was seen in regard to the success rate of surgery, rate of complications, and hospital stay after operation. CONCLUSION: After echocardiography assessment, transcatheter occluder implantation is superior than surgery for some patients with perimembranous VSD accompanied by TI.