Association of resting heart rate with pulse wave velocity and high-sensitivity C-reactive protein in hypertensive patients[J]. Chinese Heart Journal, 2011, 23(3): 351-353.
    Citation: Association of resting heart rate with pulse wave velocity and high-sensitivity C-reactive protein in hypertensive patients[J]. Chinese Heart Journal, 2011, 23(3): 351-353.
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    Association of resting heart rate with pulse wave velocity and high-sensitivity C-reactive protein in hypertensive patients

      摘要
    • 摘要: 目的:探讨高血压病患者静息心率(RHR)与脉搏波速度（PWV）、超敏C反应蛋白（hs-CRP）的关系。方法： 入选高血压病患者278例，按RHR水平分为：RHR1组：<70 次/min，RHR2组：70～79次/min，RHR3组：≥80次/min。对入选患者测定颈－股脉搏波速度（PWV），并测空腹血糖(FPG)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、超敏C反应蛋白。结果： RHR3组的SBP、DBP均高于RHR1组、RHR2组；RHR2组SBP高于RHR1组；从RHR1组、RHR2组至RHR3组FBG、TC、TG、LDL-C、PWV、hs-CRP随着RHR的增加有增高的趋势（P<0.05或P<0.01），HDL-C随着RHR的增加有减少的趋势（P<0.05）。RHR与SBP、FBG、TC、TG、LDL-C、PWV、hs-CRP呈正相关(P<0.05或P<0.01)，与HDL-C呈负相关(P<0.05)。RHR2组或RHR3组的PWV、hs-CRP显著大于或高于RHR1组。结论： 高血压病患者RHR是PWV、hs-CRP、LDL-C的相关因素。

       

      Abstract: AIM:To study the relationship between resting heart rate (RHR) and pulse wave velocity (PWV) and high-sensitivity C-reactive protein (hs-CRP) in hypertensive patients. METHODS: Two hundred and seventy-eight hypertensive patients were enrolled in the study and, according to the RHR, were divided into three groups: group RHR 1 (<70/min, n=81), group RHR 2 (70-80/min, n=113) and group RHR 3 (>80/min, n=84). RHR, blood pressure, fasting plasma glucose (FPG), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and PWV and hs-CRP were determined, and the correlation between RHR and the other parameters was analyzed. RESULTS: Both SBP and DBP in Group RHR3 are higher than in RHR1 or RHR2. SBP in Group RHR2 is higher than in Group RHR1. From Groups RHR1 and RHR2 to Group RHR3, RHP, FBG, TC, TG, LDL-C, PWV, and hs-CRP are prone to increase (P<0.05 or P<0.01), whereas HDL-C is prone to decrease (P<0.05). RHP is positively related to FBG, TC, TG, LDL-C, PWV, and hs-CRP (P<0.05 or P<0.01) and negatively related to HDL-C (P<0.05) PWV and hs-CRP in group RHR2 or group RHR3 were higher than those in RHR1. CONCLUSION: RHR is associated with PWV and hs-CRP in hypertensive patients.

       

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