刘 欣, 邬德朔, 侯贺功. 降纤酶对非ST段抬高型心肌梗死患者TNF-α、hs-CRP水平的影响[J]. 心脏杂志, 2013, 25(6): 665-667.
    引用本文: 刘 欣, 邬德朔, 侯贺功. 降纤酶对非ST段抬高型心肌梗死患者TNF-α、hs-CRP水平的影响[J]. 心脏杂志, 2013, 25(6): 665-667.
    shu
    Impact of defibrase on hsCRP and TNF-α in patients with nonST segment elevation myocardial infarction[J]. Chinese Heart Journal, 2013, 25(6): 665-667.
    Citation: Impact of defibrase on hsCRP and TNF-α in patients with nonST segment elevation myocardial infarction[J]. Chinese Heart Journal, 2013, 25(6): 665-667.
    shu

    降纤酶对非ST段抬高型心肌梗死患者TNF-α、hs-CRP水平的影响

    Impact of defibrase on hsCRP and TNF-α in patients with nonST segment elevation myocardial infarction

      摘要
    • 摘要: 目的:探讨非ST段抬高型心肌梗死（NSTEMI）患者在规范化治疗方案的基础上加用降纤酶后，对其血浆肿瘤坏死因子-α（TNF-α）、血清高敏C反应蛋白（hs-CRP）水平的影响。方法:选取我院住院的急性NSTEMI患者86例，随机分为对照组和试药组，试药组在规范化治疗方案的基础上加用降纤酶，釆用ELISA法检测血浆TNF-α浓度、胶乳增强免疫比浊法测定血清hs-CRP浓度，并评估降纤酶临床疗效。结果:试药组患者血浆TNF-α、血清hs-CRP浓度水平显著降低（均P<0.05）；试药组患者临床总有效率与对照组相比差异未达显著水平，但有明显增高趋势。结论:NSTEMI患者在规范治疗的基础上加用降纤酶后可以有效降低炎症反应指标TNF-α、hs-CRP的浓度水平。

       

      Abstract: AIM:To probe the impact of defibrase on hsCRP and TNFα in patients with nonST segment myocardial infarction (NSTEMI). METHODS: Eightysix patients with NSTEMI were randomly divided into two groups: control group and treatment group. Standardized treatment was given to the two groups and defibrase was added in the treatment group. ELISA was used to analyze plasma TNFα level and LaTeX enhanced immune turbidimetry method was employed to detect hsCRP. RESULTS: Both TNFα level and hsCRP level significantly decreased in the treatment group compared with the control group (P<0.05). There was no significant difference in the total efficiency rate between the treatment group and control group, but there was an obvious increasing tendency. CONCLUSION: On the basis of standardized treatment, defibrase decreases the levels of inflammation index (TNF-α and hsCRP) in patients with NSTEMI.

       

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