Abstract: AIM To explore the role and the correlation between high sensitive C-reaction protein and plasminogen activator inhibitor type 1 in patients of unstable angina pectoris accompanied with 2 type diabetes mellitus. METHOIDS Serum high sensitive C-reactive protein and plasma plasminogen activator inhibitor type 1 levels were measured in 149 subjects, including 40 patients with unstable angina pectoris and 2 type diabetes mellitus (UAP+DM), 56 patients with unstable angina pectors (UAP), and 53 patients with stable angina (SAP). Changes and correlation of the two inflammatory markers in different groups were studied. RESULTS Concentrations of hs-CRP in UAP+DM group were higher than those in UAP group ［(5.2±2.7)mg/L vs (3.8±1.9)mg/L］ and SAP group ［(5.2±2.7)mg/L vs (2.0±0.9)mg/L］, with significant difference. Levels of PAI-1 were also significantly different between the three groups, while the levels of the PAI-1 showed no difference between the UAP+DM group and the UAP group. The levels of the PAI-1 in the subjects with hs-CRP>3 mg/L were (1.7±0.9)A, the levels of the fasting plasma glucose (FPG) were (5.9±1.3)mmol/L and the prevalence rate of the unstable angina pectoris was 40.94%, significantly higher than the subjects with the levels of PAI-1 with hs-CRP≤3 mg/L (1.2±0.6)A, FPG (5.1±0.7)mmol/L and the prevalence rate of the unstable angina pectoris 23.48%. Positive correlation was found between the levels of hs-CRP and PAI-1(r=0.62, P<0.01), between the levels of hs-CRP and FPG (rs=0.34, P<0.01) and between the levels of PAI-1 and FPG (rs=0.38, P<0.01). CONCLUSION Inflammatory factors hs-CRP and PAI-1 in patients with unstable angina pectoris accompanied with Ⅱ type diabetes mellitus are higher than those with only coronary problems or only Ⅱ diabetes mellitus.