Abstract: Autophagy is an important biological process in which the cytoplasmic constituents of protein and impaired organelles are sequestered in a double-membrane autophagosome and then delivered to the lysosome for degradation. Selective degradation of autophagy is highly regulated by various molecules. Autophagy is an important regulatory approach of clearing damaged cellular materials and maintaining cell homeostasis and is closely related to cardiovascular disease, tumors and neurodegenerative diseases. In recent years, there has been reported a phenomenon of autophagy in viral myocarditis. In our preliminary experiments of the mouse model of viral myocarditis, we also observed the phenomenon of autophagy. This review summarizes the research progress of the relationship between autophagy and viral myocarditis.