甲状腺功能亢进与心室复极化关系的meta分析

刘国才; 周 洁; 高 彬; 孙 飞; 张妙娟; 姬秋和

甲状腺功能亢进与心室复极化关系的meta分析

A meta-analysis of the relationship between hyperthyroidism and ventricular repolarization

摘要

摘要: 目的:分析甲状腺功能亢进（甲亢）对于心室复极化的影响。方法:计算机检索PubMed、EMBASE、中国期刊全文数据库、维普数据库、万方数据库于1960年~2013年12月公开发表的相关文献，用Revman 5.2进行meta分析。结果:分析纳入7项病例对照研究，甲亢病例425例，对照组366例。甲亢时心率校正的QT间期（QTc)较对照组显著延长（MD=18.46,95%CI：10.19-26.73,P<0.01），心率校正的QT离散度(QTcd)也显著延长（MD=19.38, 95%CI：13.59-25.18,P<0.01）。QT间期与对数化后的促甲状腺素（TSH）呈负相关(Pearson相关系数r=-0.748，P<0.01；加权线性回归系数R2=0.557，P<0.01)。结论:甲亢患者的心室复极化显著延长。

Abstract: AIM:To determine whether hyperthyroidism has an effect on ventricular repolarization. METHODS: PUBMED, EMBASE, China National Knowledge Internet (CNKI), VIP-database and Wanfang Database were searched. Case-control studies focusing on hyperthyroidism and ventricular repolarization published between 1960 and 2013 were collected. RevMan 5.2 was used to perform the meta-analysis. RESULTS: The meta-analysis included seven case-control studies and a total of 425 hyperthyroid patients and 366 healthy controls were included. Compared with controls, hyperthyroid patients showed a prolonged QT interval (MD=18.46, 95%CI=10.19 to 26.73), P<0.01) and a prolonged QT interval dispersion (MD=19.38, 95%CI=13.59 to 25.18, P<0.01). Moreover, QTc was negatively correlated with the logarithm of TSH levels (Pearson correlation coefficient r=-0.748, P<0.01; weighted linear regression coefficient R2=0.557). CONCLUSION: Hyperthyroidism is associated with ventricular repolarization prolongation.

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