AT1R基因A1166C的多态性与急性心肌梗死患者冠脉病变程度的关系

Association between angiotensin II type 1 receptor gene A1166C polymorphism and extent of coronary stenosis in patients with acute myocardial infarction

摘要: 目的:研究血管紧张素Ⅱ1 型受体(AT1R)基因A1166C的多态性与急性心肌梗死(AMI)患者冠脉病变程度的关系。方法：采用多聚酶链反应-限制性片段长度多态性(PCR-RFLP)技术检测105例初发AMI患者的AT1R基因A1166C的多态性。对所有患者进行冠脉造影，根据结果判定冠脉病变的支数(狭窄程度≥50%)和冠脉病变的Gensini积分。结果： AMI患者中，AC+CC基因型携带者冠脉病变的支数和Gensini积分均显著高于AA基因型携带者（P<0.05）。结论： AT1R基因A1166C的多态性与AMI患者冠脉病变程度有关。

Abstract: AIM:To study the relationship between the angiotensin II type 1 receptor (AT1R) gene A1166C polymorphism and the extent of coronary stenosis in patients with acute myocardial infarction (AMI). METHODS: The A1166C polymorphism of 105 primary AMI patients was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). All patients underwent coronary angiography, and the number of affected coronary vessels (≥50% stenosis) and the coronary Gensini score were determined by the results of coronary angiography. RESULTS: Either the number of affected coronary vessels or the coronary Gensini score in AC+CC genotype carriers was significantly higher than in AA genotype carriers (P<0.05). CONCLUSION: The AT1R gene A1166C polymorphism may be related to the extent of coronary stenosis in AMI patients.