Abstract: AIM To investigate the association of single nucleotide polymorphism of ANGPTL2 gene with infarct-related artery spontaneous reperfusion in patients with ST-segment elevation myocardial infarction (STEMI). METHODS Genomic DNA was extracted from the peripheral blood of 36 cases of spontaneous reperfusion (SR) patients and 62 cases of non-spontaneous reperfusion (NSR) patients. Three SNPs (rs999092 (A>G), rs11792699 (A>G) and rs13298677 (A>G) of Angptl2 gene were amplified with fluorescence quantitative PCR and were detected by Sanger sequencing. The results were compared with the standard sequence of UCSC gene library and the differences of SNP locus genotype and allele frequencies in the two groups were analyzed. RESULTS Uric acid, white blood count, and mean platelet volume (MPV) in the SR group were lower than those in the NSR group. Logistic regression analysis showed that uric acid and MPV were independent predictors of SR and were negatively correlated with the occurrence of SR. No significant difference was found in the genotype and allele frequencies in 3 SNPs between the two groups. CONCLUSION Single nucleotide polymorphism of ANGPTL2 gene is not the cause of differential expression of ANGPTL2 in platelets between SR and NSR groups and is not correlated with spontaneous recanalization of infarct artery.