Abstract: AIM：To investigate the clinical and coronary angiographic profile and C-reactive protein (CRP) and their relation with coronary heart disease (CHD) in female patients aged below 45. METHODS: Ninety-two female inpatients (aged ≤45 years) with confirmed CHD by coronary angiography in our hospital from January 2000 to January 2008 were included in the study, and their clinical and coronary angiographic characteristics were investigated retrospectively. RESULTS: Significant difference of hypertension, diabetesmellitus, hyperlipidemia, CRP and HDL-C was found in the patients under study（P<0.05）. The CHD family history ratio in the female patients was significantly higher than that in male counterparts, and their blood uric acid ratio was significantly lower than that in male counterparts（both, P<0.05）. In the female patients, the single lesion accounted for 61%, the left anterior descending branch of culprit and calcified vessels for 43%, the unstable angina pectoris for 69% and the acute cardiac infarction for 7%. The levels of CRP were positively correlated to the number of lesions of coronary artery disease. CONCLUSION: Female CHD patients aged below 45 have higher risk factors to be complicated by hypertension, diabetes, HDL-C, CRP and hyperlipidemia but have lower ratios of blood uric acid. The increase of the level of CRP could be an independent risk factor to predict CHD in female patients.