Abstract: AIMTo explore the correlation between protein KRT8, ANK1 and coronary heart disease. METHODSWe recruited 50 patients confirmed by coronary angiography as having coronary heart disease, and 20 patients with negative coronary angiography results were assigned to control group. We performed enzyme immunosorbent assay to test the concentrations of KRT8 and ANK1 from the peripheral blood plasma of all subjects. Degrees of coronary stenosis in patients with coronary artery disease were scored using the standard of the Gensini score. RESULTSConcentrations of KRT8 and ANK1 in patients with coronary heart disease were significantly higher than those in the control group (P<0.05). Concentrations of KRT8 and ANK1 between high and low Gensini scores were significantly different in patients with coronary artery disease (P<0.05) and the concentration differences of ANK1 and KRT8 were positively correlated with Gensini scores. CONCLUSIONKRT8 and ANK1 are associated with coronary heart disease and are positively correlated with the severity of the lesions.