芪丹通脉片治疗心绞痛的疗效分析

马静; 王宗仁; 孙静; 姚菊峰; 龙铟; 行利

芪丹通脉片治疗心绞痛的疗效分析

Effect of qidantongmai tablet in the treatment of angina pectoris

摘要

摘要: 目的: 观察芪丹通脉片(QDTMT )治疗冠心病心绞痛的临床疗效。方法: 将 205 例心绞痛患者，随机分为芪丹通脉片组和养心氏组；分别口服芪丹通脉片 4 片，养心氏片2 片，观察患者心绞痛发作次数、疼痛程度、持续时间、硝酸甘油服用量，以及胸闷、心悸、气短、倦怠乏力、自汗等中医症候和心电图的变化。结果: 芪丹通脉片组患者心绞痛总有效率为78.6%、显效率35.9%，养心氏组总有效率为71.5%、显效率30.3%，芪丹通脉片组中医证候显效率35.9 %、总有效率为 91.3 %，养心氏组显效率27.5 %，总有效率为86.4%，芪丹通脉片组心电图总有效率45.6%、显效率21.4%，养心氏组总有效率34.3%、显效率9.8%；两组心绞痛和中医证候总有效率相比无统计学差异，而芪丹通脉片组心电图总有效率显著高于养心氏组（P<0.05）。结论: 芪丹通脉片对心绞痛有较好的临床疗效。

Abstract: AIM: To observe the effect of qidantongmai tablet (QDTMT) in the treatment of angina pectoris (AP). METHODS: Two hundred and five patients were randomized into QDTMT group and yangxinshi tablet (YXST) group. QDTMT (4 pills/day) and YXST (2 pills/day) were given, respectively, in the two groups for 28 days. The following changes were observed: frequency, persistence time and degree of pain of AP, dose of nitroglycerin used, chest distress, breath holding, arrhythmia, shortness of breath, lassitude and hypodynamia, spontaneous perspiration and electrocardiogram (ECG) changes. RESULTS: After 28 days, the total effective rate and excellence rate were 78.6% and 35.9% in QDTMT group, respectively, whereas those in YXST group were 71.6% and 30.4%, respectively. Total effective rate and excellence rate of traditional Chinese medicine symptoms were 91.3% and excellence rate was 35.9% in QDTMT group, whereas those were 86.4% and 27.5%, respectively, in the YXST group. ECG results showed that the total effective rate and the excellence rate were 45.6% and 21.4%, respectively, in the QDTMT group, whereas those were 34.3% and 9.8% in YXST group, respectively. No significant difference was found in the total effectiveness rate of AP and traditional Chinese medicine symptoms between QDTMT group and YXST group, but EKG results showed significant difference between the groups (P<0.05). CONCLUSION: QDTMT is effective in treating AP.

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