Abstract: Wnt signaling plays a key role in cell differentiation, embryonic development, tumorigenesis and angiogenesis. Recent studies have found that genetic interventions in Wnt signaling at different levels resulted in an attenuated hypertrophic response. Inhibiting Wnt signaling may thus serve as a novel therapeutic approach for cardiac hypertrophy. We reviewed the research findings on the relationship between Wnt signaling and cardiac hypertrophy and discussed the promising target for anti-hypertrophic therapy.