支架植入术对急性冠脉综合征炎症过程的影响及其与再狭窄的关系

Variance of IL-6, IL-10, and MMP-1 in patients with acute coronary syndrome after percutaneous coronary intervention and the interrelation of cytokines and restenosis

摘要: 目的: 探讨急性冠脉综合征（ACS）患者经支架植入术（PCI）后对血清IL-6、IL-10和基质金属蛋白酶1（MMP-1）的影响及再狭窄与各炎症因子的关系。方法: 选取ACS行冠脉支架植入术患者64例，并于术前、术后不同时间段分别采取外周静脉血，测定血清IL-6、IL-10、MMP-1的浓度，跟踪随访6个月，对冠脉再狭窄患者进行统计。结果: 冠脉支架植入术后IL-6、MMP-1浓度明显高于术前，24 h达到高峰，IL-6于术后1周、MMP-1于术后1个月降至术前水平；冠脉再狭窄组术前、术后24 h IL-6、MMP-1浓度明显高于非再狭窄组。结论: 冠脉支架植入术增加了血清炎症因子的水平，并能对冠脉再狭窄进行预测。

Abstract: AIM: To detect the variance of IL-6, IL-10, and MMP-1 in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI) and the interrelation of cytokines and restenosis. METHODS: Serum concentrations of IL-6, IL-10 and MMP-1 were measured in 64 patients with ACS. Pre- and post-PCI was done by enzyme-linked immunosorbent assay (ELISA), and patients were followed-up after 6 months. RESULTS: Serum concentrations of IL-6 and MMP-1 significantly increased after PCI. When comparing the restenosis group to the no-restenosis qroup, they are different both pre- and post-PCI. CONCLUSION: Serum inflammatory levels were augmented by PCI and may predict restenosis.